The AHPBA Podcast

Episode 29: Dr. D. Rohan Jeyarajah – Private Practice in HPB and the Modern Academic Surgeon

Today’s episode features a special guest, Dr. Rohan Jeyarajah.  Dr. Jeyarajah is a hepatobiliary and complex GI surgeon, inaugural chair and professor of surgery at the TCU Burnett School of Medicine, and program director for the HPB and Complex GI surgical fellowships at Methodist System.  He has a unique practice in the world of HPB, combining private practice and academics, which we were delighted to discuss today.  Enjoy!

 

Papers References in Episode:

Jackson T, Lim JS, Cho E, Osman H, Nagatomo K, Jeyarajah DR. Hepatopancreatobiliary Fellowship Graduates: Where Do They Stand today? Am Surg. 2022 Jun;88(6):1250-1255. doi: 10.1177/0003134821995066. Epub 2021 Feb 10. PMID: 33565895.

Episode 28: Dr. Maithel – The Surgeon Scientist & Surgeon-Led Clinical Trials in Biliary Tract Cancer

Today’s episode features Dr. Shishir Maithel.  Dr. Maithel is a hepatobiliary surgeon, professor of surgery, and chief of the division of Surgical Oncology at a Northwestern University.  He holds multiple national leadership positions, including as chair of the gastrointestinal surgery working group of ECOG and a member of the scientific and medical advisory board of the international cholangiocarcinoma research network.  Dr. Maithel leads multiple clinical trials in the field of HPB and we are excited today to discuss his many national and international research efforts.  Enjoy!

 

Papers Referenced in Episode:

1. Maithel, S. K., Keilson, J. M., Cao, H. S. T., Rupji, M., Mahipal, A., Lin, B. S., ... & Rocha, F. G. (2023). NEO-GAP: a single-arm, phase II feasibility trial of neoadjuvant gemcitabine, cisplatin, and nab-paclitaxel for resectable, high-risk intrahepatic cholangiocarcinoma. Annals of surgical oncology, 30(11), 6558-6566.
2. Oh DY, Ruth He A, Qin S, Chen LT, Okusaka T, Vogel A, Kim JW, Suksombooncharoen T, Ah Lee M, Kitano M, Burris H, Bouattour M, Tanasanvimon S, McNamara MG, Zaucha R, Avallone A, Tan B, Cundom J, Lee CK, Takahashi H, Ikeda M, Chen JS, Wang J, Makowsky M, Rokutanda N, He P, Kurland JF, Cohen G, Valle JW. Durvalumab plus Gemcitabine and Cisplatin in Advanced Biliary Tract Cancer. NEJM Evid. 2022 Aug;1(8):EVIDoa2200015. doi: 10.1056/EVIDoa2200015. Epub 2022 Jun 1. PMID: 38319896.
3. Goyal L, Meric-Bernstam F, Hollebecque A, Valle JW, Morizane C, Karasic TB, Abrams TA, Furuse J, Kelley RK, Cassier PA, Klümpen HJ, Chang HM, Chen LT, Tabernero J, Oh DY, Mahipal A, Moehler M, Mitchell EP, Komatsu Y, Masuda K, Ahn D, Epstein RS, Halim AB, Fu Y, Salimi T, Wacheck V, He Y, Liu M, Benhadji KA, Bridgewater JA; FOENIX-CCA2 Study Investigators. Futibatinib for FGFR2-Rearranged Intrahepatic Cholangiocarcinoma. N Engl J Med. 2023 Jan 19;388(3):228-239. doi: 10.1056/NEJMoa2206834. PMID: 36652354.
4. Kelley RK, Ueno M, Yoo C, Finn RS, Furuse J, Ren Z, Yau T, Klümpen HJ, Chan SL, Ozaka M, Verslype C, Bouattour M, Park JO, Barajas O, Pelzer U, Valle JW, Yu L, Malhotra U, Siegel AB, Edeline J, Vogel A; KEYNOTE-966 Investigators. Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2023 Jun 3;401(10391):1853-1865. doi: 10.1016/S0140-6736(23)00727-4. Epub 2023 Apr 16. Erratum in: Lancet. 2023 Sep 16;402(10406):964. doi: 10.1016/S0140-6736(23)01904-9. Erratum in: Lancet. 2024 Mar 23;403(10432):1140. doi: 10.1016/S0140-6736(24)00545-2. PMID: 37075781.
5. Zhu AX, Macarulla T, Javle MM, Kelley RK, Lubner SJ, Adeva J, Cleary JM, Catenacci DVT, Borad MJ, Bridgewater JA, Harris WP, Murphy AG, Oh DY, Whisenant JR, Lowery MA, Goyal L, Shroff RT, El-Khoueiry AB, Chamberlain CX, Aguado-Fraile E, Choe S, Wu B, Liu H, Gliser C, Pandya SS, Valle JW, Abou-Alfa GK. Final Overall Survival Efficacy Results of Ivosidenib for Patients With Advanced Cholangiocarcinoma With IDH1 Mutation: The Phase 3 Randomized Clinical ClarIDHy Trial. JAMA Oncol. 2021 Nov 1;7(11):1669-1677. doi: 10.1001/jamaoncol.2021.3836. PMID: 34554208; PMCID: PMC8461552.
6. Harding JJ, Fan J, Oh DY, Choi HJ, Kim JW, Chang HM, Bao L, Sun HC, Macarulla T, Xie F, Metges JP, Ying J, Bridgewater J, Lee MA, Tejani MA, Chen EY, Kim DU, Wasan H, Ducreux M, Bao Y, Boyken L, Ma J, Garfin P, Pant S; HERIZON-BTC-01 study group. Zanidatamab for HER2-amplified, unresectable, locally advanced or metastatic biliary tract cancer (HERIZON-BTC-01): a multicentre, single-arm, phase 2b study. Lancet Oncol. 2023 Jul;24(7):772-782. doi: 10.1016/S1470-2045(23)00242-5. Epub 2023 Jun 2. PMID: 37276871.
7. Primrose JN, Fox RP, Palmer DH, Malik HZ, Prasad R, Mirza D, Anthony A, Corrie P, Falk S, Finch-Jones M, Wasan H, Ross P, Wall L, Wadsley J, Evans JTR, Stocken D, Praseedom R, Ma YT, Davidson B, Neoptolemos JP, Iveson T, Raftery J, Zhu S, Cunningham D, Garden OJ, Stubbs C, Valle JW, Bridgewater J; BILCAP study group. Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study. Lancet Oncol. 2019 May;20(5):663-673. doi: 10.1016/S1470-2045(18)30915-X. Epub 2019 Mar 25. Erratum in: Lancet Oncol. 2019 May;20(5):e242. doi: 10.1016/S1470-2045(19)30216-5. PMID: 30922733.

Clinical Trials:

1. https://clinicaltrials.gov/study/NCT05514912 (The OPTIC Trial)
2. https://clinicaltrials.gov/study/NCT03579758?cond=gallbladder%20cancer&term=maithel&rank=1 (Chemotherapy Before & After Surgery in Patients with Resectable Gallbladder Cancer)

Episode 27: Dr. Guido Torzilli — The Philosophy of Modern Liver Surgery and More

We are excited to welcome Dr. Guido Torzilli to the podcast! Dr. Torzilli is a world-renowned hepatobiliary surgeon and Professor of Surgery at Humanitas University in Milan, Italy. In this episode, we have a fantastic conversation about his career, the concepts that have shaped his extraordinary and innovative approach to liver surgery, and much more!

Episode 26: Dr. David Iannitti—Innovation in Surgery and the Past, Present, and Future of Liver Ablation

We are excited to welcome Dr. David Iannitti to the podcast!  Dr. Iannitti is a hepatobiliary surgeon, professor of surgery, program director of the HPB fellowship, and the chief of the HPB Surgery Division at Atrium Health in Charlotte, North Carolina.  His clinical and research interests include the pathophysiology of hepatocellular carcinoma and other therapies for liver lesions.  We’re excited to share a fantastic conversation discussing history and innovations of electrosurgery, novel therapies for liver disease, and much more!

Papers Referenced in Episode:

1. Swan, R. Z., Tsirline, V., Sindram, D., Martinie, J. B., & Iannitti, D. A. (2012). Fundamentals of microwave physics: application to hepatic ablation. Journal of Microwave Surgery, 30, 25-40.
2. Ricker AB, Baker EH, Strand MS, Kalabin A, Butano V, Wells A, Phillips M, Wang H, McKillop I, Iannitti G, Casingal J, Martinie JB, Vrochides D, Iannitti DA. Surgical microwave ablation for the treatment of hepatocellular carcinoma in 791 operations. HPB (Oxford). 2024 Mar;26(3):379-388. doi: 10.1016/j.hpb.2023.11.009. Epub 2023 Nov 25. PMID: 38102029.
3. Wells AB, Butano VW, Phillips MC, Mckillop IH, Martinie JB, Baker EH, Iannitti DA. Outcomes after Surgical Microwave Ablation for the Treatment of Colorectal Liver Metastasis. J Am Coll Surg. 2024 Apr 23. doi: 10.1097/XCS.0000000000001097. Epub ahead of print. PMID: 38651746.
4. Davis JM, Salibi PN, Motz BM, Vrochides D, McKillop IH, Iannitti DA. Irreversible Electroporation-Assisted Resection for Locally Advanced Pancreas Cancer. Surg Innov. 2023 Jun;30(3):332-339. doi: 10.1177/15533506231157442. Epub 2023 Feb 15. PMID: 36792137.

 

ECG Overtime: Episode 7 - Getting Involved in Surgical Societies, Live from Cape Town

The early career group of IHPBA presents recording from discussions at the Early Career Retreat and ECG Lounge sessions from the 2024 IHPBA World Congress in Cape Town.

In this episode, we join the ECG Lounge where past and current presidents of HPB surgery societies talk with early career IHPBA attendees about how to get involved in surgical societies like the IHPBA. Listen to Drs. Marc Besselink (president of EAHPBA), Sean Cleary (immediate past president of AHPBA), Rebecca Minter (past president of AHPBA), and Shailesh Shrikhande (president of APHPBA) answer questions from early career surgeons and provide advice on how to engage in surgical societies. Discussions are moderated by Drs. Mary Dillhoff and Janet Kung.

ECG Overtime: Episode 6 - The New HPB Surgeon, Beyond Surgery

Join us for another episode of our series ECG Overtime, hosted by the E-AHPBA/IHPBA Early Career Group!  This episode features Dr. Sanket Srinivasa, Dr. Tay Wee Ming, and Dr. Saneya Pandrowala.  Enjoy an episode in which we continue the conversation started during the Asia/Pacific Webinar about life beyond surgery as a new HPB surgeon!  

Latín América-Episodio #35. Dr. Roberto Hernandez Alejandro. Transplante of Colorectal Liver Metastasis.

El Dr. Roberto Hernandez-Alejandro ha sido Jefe de la División de Trasplantes en la Universidad de Rochester desde agosto de 2016. Bajo su liderazgo, expandió las oportunidades de trasplante mediante el aumento del uso de órganos donados después de la muerte cardíaca. Recientemente, el Dr. Hernandez abrió un programa de trasplante hepático para metástasis hepáticas de cáncer colorrectal irresecable, siendo actualmente el centro líder en volumen y resultados en América del Norte. También tiene experiencia en resecciones hepáticas y es uno de los pocos cirujanos en Estados Unidos que realiza el procedimiento ALPPS.

ECG Overtime: Episode 5 - Live from Cape Town - International Collaborations: The GECKO Model

The early career group of IHPBA presents recording from discussions at the Early Career Retreat and ECG Lounge sessions from the 2024 IHPBA World Congress in Cape Town.

In this episode, Drs. Ewen Harrison and Deirdre Kruger review opportunities and lessons learned from international collaborations in global surgical research, using the example of the GlobalSurg network and the GECKO study, along with moderators Drs. Timothy Newhook and Julia Menso.

ECG Overtime: Episode 4 - Live from Cape Town - Taking Part in the Editorial Process

The early career group of IHPBA presents recording from discussions at the Early Career Retreat and ECG Lounge sessions from the 2024 IHPBA World Congress in Cape Town.

In this episode, we discuss challenges and controversies in the editorial process, with a focus on the involvement of trainees and early career surgeons, with Drs. Giovanni Marchegiani, Rachel Guest, and David Cavalucci, along with moderators Drs. Timothy Newhook and Julia Menso. Hear about how to get started and get credit for peer-review, select a journal for publication, and controversies about sustainability of the current publishing model. Should peer-reviewers be compensated? Should we move towards fully open access publishing? Should we get rid of impact factors?

ECG Overtime: Episode 3 - Live from Cape Town - Getting Published: Tips from the Editor

The early career group of IHPBA presents a recording from discussions at the Early Career Retreat and ECG Lounge sessions from the 2024 IHPBA World Congress in Cape Town.

In this episode, Dr. Stephen Wigmore, Editor-in-Chief of HPB, reviews tips to get a manuscript published, with moderators Drs. Timothy Newhook and Julia Menso.